This article discusses the methodological differences between the British school and the American school of international relations. It attempts to demonstrate that Susan Strange, representative of the British school, could be considered a critical realist. The aim of the article is to show that her vision of international political economy fulfills the methodological reorientation initiated in economics by Tony Lawson at the end of the 90s. Strange's radical ontology claims that structural power determines human actions. The paper contrasts Strange's approach with that of John Ruggie, from the American school, who identifies himself as a social constructivist. Ruggie emphasizes the role of ideational factors in international relations and the constructed nature of social reality.